賀!!! 環醫中心李建宏教授-檳榔團隊(檳榔研究)投至Jama Psychiatry的論文刊登接受信函，恭喜!
Topic: DSM-5 Betel-Quid Use Disorder and Oral Potentially Malignant Disorder: A Joint Addiction Study on Six Betel-Quid-Endemic Asian Populations
1.Ko AM, Hung CC, Yang FM, Warnakulasuriya S, Ibrahim OS, Zain RB, Lee CH*, Ko YC*. DSM-5 betel-quid use disorder and oral potentially malignant disorder: A joint addiction study on six betel-quid-endemic Asian populations. Jama Psy, 2017 (in press).
SCI, Impact Factor: 15.307, Rank: 2/142, 2016
Subject Categories: PSYCHIATRY
Anal Chem. 2017 Oct 17;89(20):10883-10888. doi: 10.1021/acs.analchem.7b02544. Epub 2017 Oct 4.
Design of Peptide-Based Probes for the Microscale Detection of Reactive Oxygen Species.
Keng CL1, Lin YC2, Tseng WL3, Lu CY1,4,5,6.
1.Research Center for Environmental Medicine, Kaohsiung Medical University , Kaohsiung 80708, Taiwan.
2.School of Pharmacy, College of Pharmacy, Kaohsiung Medical University , Kaohsiung 80708, Taiwan.
3.Department of Chemistry, College of Science, National Sun Yat-sen University , Kaohsiung 80424, Taiwan.
4.Department of Biochemistry, College of Medicine, Kaohsiung Medical University , Kaohsiung 80708, Taiwan.
5.Institute of Medical Science and Technology, National Sun Yat-sen University , Kaohsiung 80424, Taiwan.
6.Department of Medical Research, Kaohsiung Medical University Hospital , Kaohsiung 80708, Taiwan.
Reactive oxygen species (ROS) can induce oxidative stress and are associated with cell death and chronic diseases in organisms. In the treatment of disease, drugs that induce ROS are associated with many side effects and unpleasant symptoms. Therefore, during the assessment of new drugs and candidate compounds, ROS generation is an issue of concern, because ROS can modify proteins, lipids, and nucleic acids within organisms and alter their biological functions. In this work, we designed a peptide-based probe for the rapid (<10 min) high-throughput survey of oxidative stress induced by clinical drugs at the microliter level. Using menadione and H2O2 as positive controls, just 100 μg/mL of the test compound and 100 μg/mL of the probe were sufficient to effectively monitor the generation of ROS, which is important as many active compounds are rare and difficult to isolate or purify. This in vitro evaluation could be used to effectively generate preliminary data before pharmacologically active candidate compounds are processed in cell-line or animal tests. Furthermore, we demonstrated that this peptide probe successfully detects ROS in biological samples.