Within this research theme, RCPEM actively integrates intervention studies and evidence-based tracking on the research side, community health services on the medical side, and university social responsibility projects on the educational side. It engages deeply with the community to establish the optimal translational field for environmental medicine. This year, our research teams have published 24 papers in this area, 17 of which have been published in high quality journals (impact factor >5 or ranked in the top 10% in each field). Our achievements include the following:

1. We integrated the measurement and modelling expertise of Dr Yu-Cheng Chen at the National Health Research Institutes (NHRI) to evaluate the quantification of PM2.5 using a machine learning technique with a cluster algorithm coupled with a backward trajectory. The result suggests that traffic-related emissions are the major sources of PM2.5-metals in Taiwan (Environ Pollut. 2023 ;316(Pt 2):120652).
2. Using a simulated cooking oil fume exposure chamber and sampling techniques, trans,trans-2,4-decandienal (ttDDE), a genotoxin, was found to be the major component of cooking oil fumes. In addition, the results of an in vivo study suggested that ttDDE exposure could induce lung tumours in mice.
3. We have successfully established a sampling technique for avian influenza viruses in the atmosphere. It will be helpful for early warning and reducing disaster losses. The research results were published in the journal "Environmental Science & Technology" and covered by numerous social media.
4. We implemented and actively promoted the miniaturised design of the "simple and economical oil fume absorption sealed barrel" to mitigate the harm of cooking fume exposure to the public. In addition to visits from street vendors seeking information, the public also inquired about the assembly methods and usage through social media platforms. We also provided guidance to Hong Kong restaurants on improving their equipment.
5. The "Pulmonary Health Clinic", which integrated data from Airbox and the Environmental Protection Bureau's air quality monitoring station as a reference for disease and prescription changes, won the 24th National Healthcare Quality Award. (6) We actively researched the effects of environmental arsenic exposure on lung function and patented a series of apigenin skeleton derivatives to reduce arsenic exposure in the body.

1. Our study of Taiwanese women and their children confirmed that exposure of mono-n-buty1 phthalate (MnBP) in women during the late stages of pregnancy led to low birth weights in male infants or weights below those appropriate for gestational age. These results were published in Science of the Total Environment.
2. We found that reducing exposure to environmental plasticizers and melamine in daily life can help reduce the risk of early kidney damage. This finding was not only published in the esteemed journal, Environment International, but it was also translated into a form appropriate for health education purposes and published in the 935th issue of the National Health Research Institutes' e-newsletter.
3. The Center enlisted the integrated risk assessment expertise of Dr. Chu-Chih Chen at the National Health Research Institutes to consider the possible synergistic interaction of multiple toxicants. We found that tolerable daily intake (TDI) of melamine and DEHP (di(2-ethylhexyl) phthalate) should be more rigorously formulated to take into account the effect of simultaneous exposure of the two toxicants on public health. This result was published in Environmental Research and was reported in the 935th issue of the National Health Research Institutes' e-newsletter.
4. In order to promote public health education, the Center gathered research results over the years and cooperated with different disciplines of experts to create the "Environmental Hormone Awareness Handbook - Plasticizers" (in Chinese) and designed a public education poster entitled "Find out the plasticizer monsters in the living environment" (in Chinese). These projects have contributed substantially to the awareness of public health in Taiwan.
5. Our research team members cooperated with industry technological engineers to develop a "portable quantitative melamine detector," winning the 19th National Innovation Award-Clinical Innovation Award in 2022.

1. We found the co-exposure of melamine and oxalate accelerates kidney injury via excess oxidative stress, suggesting the tolerable daily intake (TDI) of melamine should be adjusted in different susceptible populations (Ecotoxicol Environ Saf., 2021, 225:112756.).
2. We integrated the risk assessment expertise of Dr. Chu-Chih Chen at National Health Research Institutes (NHRI) to evaluate the melamine exposure threshold in early chronic kidney disease (CKD) patients. We found that early-stage CKD patients should strictly refrain from using melamine tableware and related melamine-made products (Environ Int., 2021, 156:106652). These research findings were also translated into the health education articles and published on the NHRI website (https://reurl.cc/pxEDEb).
3. We found that co-exposure of the two toxicants, melamine and phthalates, might be associated with markers of early kidney injury in pregnant women (Chemosphere., 2021, 272:129925).
4. We found that dermal DEP level to be significantly associated with a decrease in lung function test values, suggesting asthmatic individuals should avoid environmental exposure to phthalates (Environ Res., 2021, 194:110613).