高雄醫學大學精準環境醫學研究中心

	Issue	Specific Academic Publication	Award / Translation
Academic Innovation	Melamine	Published medical journals including Kidnry International, JAMA Internal Medicine and Journal of the American Society of Nephrology etc.	International: The results cited by website of Time magazine, Asian Scientist and official website of American Chemical Society. Domestic (Won 3 awards): Received “2012 Taiwan Urology Association Research Award-Clinical Section, “2011 Taiwan Epidemiology Association Research Award” and “2015 Professor Chen Gongbei Memorial Award”.
Academic Innovation	Phthalates Incident (including food safety)	Published in Environment International, Environment Science & Technology, Scientific Reports, J Agric Food Chem, Oncotarget and FASEB J etc.	Domestic (Won 7 awards): “2013 International Conference of Industrial Hygiene & Occupational Medicine Research Award”, “2015 International Conference on Industrial Hygiene and Occupational Medicine”, “2015 and 2016 International Symposium of Environmental Medicine - The Best Poster Award”, “2017 The Taiwanese Menopause Society - The First Price of Oral Presentation” and “2011 Taiwan Epidemiology Association Research Award”.
Training of Talents	Thermoregulation	Published in Nature	Climate change and extreme weathers are great threats to public health, and susceptible population such as elders, pregnant women, infant and children are especially vulnerable, the Center places efforts on novel research to investigate the molecular mechanism of temperature regular.
Specialized Analysis Platform	Screening of Drug, Toxin and Food safety Analysis Platform	Published in Rapid Commun Mass Spectrom and Journal of Mass Spectrometry. Among them, one is even featured on the cover of Journal of Mass Spectrometry.	We are strategic alliance with the Rapid Screening Research Center at National Sun Yat-sen University. Facilities of the Rapid Screening Research Center is located in the Research Center for Environmental Medicine which included high throughput platform to detect drugs and toxins (eg. pesticides) from biological sample (blood or urine). The Center had established a stock of 80 toxic references to aid emergency medical responses.
	Environmental Bioinformatics Analysis Platform	Published in J Cheminform, a top journal in bioinformatics	The Platform integrate a database of chemical compounds, protein-protein interactions, gene function, pathway, diseases and other big data to provide analysis for more than 400,000 compounds. The Center hosts one of the largest environmental bioinformatics databases in the world.
	Food Safety Analysis and Predictive Modeling Platform	In collaboration with the National Center for High-performance Computing and Department of Health, Kaohsiung City Government, the Center uses the Big Data and the deep learning from Artificial Intelligence to perform surveillance and prediction of food safety incidents. We establish an early warning mechanism on food safety incidents in order to gather information of food safety and direct local and central government to the issue immediately.

	Issue	Specific Academic Publication
Academic Innovation	Melamine	Liu, C.C., et al. (2011). Low exposure to melamine increases the risk of urolithiasis in adults. Kidney Int 80(7): 746-52 (UROLOGY & NEPHROLOGY, 3/69=4.3%; IF: 6.105) Wu, C.F., et al. (2013). A crossover study of noodle soup consumption in melamine bowls and total melamine excretion in urine. JAMA Intern Med 173(4): 317-319 (MEDICINE, GENERAL & INTERNAL, 7/155=4.5%; IF: 10.579) Wu, C.F., et al. (2015). Ambient melamine exposure and urinary biomarkers of early renal injury. J Am Soc Nephrol 26(11): 2821-2829 (UROLOGY & NEPHROLOGY, 3/78=3.8%; IF: 9.343)
Academic Innovation	Phthalates Incident (including food safety)	Wu, M.T., et al. (2012). The public health threat of phthalate-tainted foodstuffs in Taiwan: the policies the government implemented and the lessons we learned. Environmental Int 44: 75-79 (ENVIRONMENTAL SCIENCES, 7/205=3.4%; IF: 5.297) Wu, C.F., et al. (2013) Temporal changes of urinary oxidative metabolites of di(2-ethylhexyl)phthalate after the 2011 phthalate incident in Taiwanese children: findings of a six month follow-up. Environ Sci Technol 47(23): 13754-13762 (ENVIRONMENTAL SCIENCES, 7/210=3.3%; IF: 5.257) Lin, P.I., et al. (2017) Soap and the removal of di-(2-ethylhexyl)phthalate from hands: N-of-1 and crossover designs. Sci Rep 7(1): 454. (MULTIDISCIPLINARY SCIENCES, 10/64=15.6%; IF: 4.259) Wang, Y.C., et al. (2016) Benzyl butyl phthalate promotes breast cancer stem cell expansion via SPHK1/S1P/S1PR3 signaling. Oncotarget 7(20):29563-29576 (ONCOLOGY, 36/213=16.9%; IF: 5.008) Hsu, Y.L., et al. (2014) Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein. J Agric Food Chem 62(49): 11933-11940 (AGRICULTURE, MULTIDISCIPLINARY, 2/56=3.57%; IF: 3.107) Hsieh, T.H., et al. (2012) Phthalates induce proliferation and invasiveness of estrogen receptor-negative breast cancer through the AhR/HDAC6/c-Myc signaling pathway. FASEB J 26(2):778-787 (BIOLOGY, 7/85=8.24%; IF: 5.712)
Training of Talents	Thermoregulation	Tan, C. H. and McNaughton, P. A. (2016) The TRPM2 ion channel is required for sensitivity to warmth. Nature 536(7617), 460-463. (MULTIDISCIPLINARY SCIENCES, 1/64; IF: 40.137)
Specialized Analysis Platform	Screening of Drug, Toxin and Food safety Analysis Platform	Lee, C.W., et al. (2016) Rapid point-of-care identification of oral medications in gastric lavage content by ambient mass spectrometry in the emergency room. Rapid Commun Mass Spectrom 30(11), 1295-1303. Lee, C.W., et al. (2016) Rapid identification of pesticides in human oral fluid for emergency management by thermal desorption electrospray ionization/mass spectrometry. J Mass Spectrom 51(2), 97-104.
Specialized Analysis Platform	Environmental Bioinformatics Analysis Platform	Tung, C.W. (2015) ChemDIS: a chemical-disease inference system based on chemical-protein interactions. J Cheminform 7, 25. (COMPUTER SCIENCE, INFORMATION SYSTEMS, SCIE, 4/138=2.89%; IF:4.547)

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